Upcoming conferences 2008
Friday, June 29th, 2007ASME Summer Bioengineering conference , Marco Island, Florida
June 25-29, 2008
http://divisions.asme.org/bed/events/sbc2008.html
deadline to submit abstracts: January 31, 2008
Archive for June, 2007
Complex Biomedical devices 2
Wednesday, June 27th, 2007As sue has mentioned in the comments of the previous post, at the first glance, cool.click™may seem a combination product, however it has to be categorized in one group to get through the legislations.
Normally, a device that is just used to DELIVER a drug ( as a syringe) is considered as a pharmaceutical product and should get through pharmaceutical legislations. However, sometimes this is the company who decides what is a main function of the product and how it wants to introduce its product and then gets through negotiations with legislative organisations to reach to an agreement about the nature of the product.
Does the device do something more than the drug delivery? Do mechanical parts or electronical parts have physical roles in the treatment,etc? These questions arise while deciding the category of the product. an example may be a coated stent.
In conclusion , It should be considered that the answer to these questions are not always very clear. Sometimes a product may be accepted as a medical device in Europe while as a pharmaceutical product in US and vice versa. The descision is made after discussions between companies and EMEA in Europe or FDA in the US.
Be care be healthy.
Saturday, June 23rd, 2007By vital statistics americans are living longer. May be the main course of this is more spending on healthcare, some about 2 trillion dollars a year. And that is very right, because if you don’t care about your own health who will? “Today, health care is primitive because even the best medications treat only a few of the people for whom they are prescribed”, Dr. Eric Topol, a nationally known and controversial expert on heart disease said. “Many individuals who take drugs cope not just with the expense, but with negative side effects that provoke the use of even more drugs.”
“We’re like the blind man with the elephant,” said Topol, 52, formerly provost and chief academic officer of the world-renowned Cleveland Clinic. He resigned from the clinic last year after clashing with colleagues and facing accusations of unethical ties to a hedge fund that traded stock in Merck, whose Vioxx drug he was criticizing.
But the medical science is not asleep too searched new way to prevent illnesses and to treat them.
For example Nanotechwire.com reports on clever work at UCSD on detecting cancer that allow to detect early-stage cancer will require the development of sensitive assays that can identify simultaneously multiple biomarkers associated with malignant cells.
Health Forums
Tuesday, June 12th, 2007I want to take a minute to bring your attention to the website myforumabout.com which has some outstanding health forums here. Health related forums are becoming increasingly popular and these ones are sure to make the grade. Whether you have a disease that you need information on or are looking for a support group, be sure to check out these health forums. You’ll be glad you did and your mind and body will thank you for it. I know that if I was suffering from a debilitating disease that I would want to find others who were in the same boat. It’s not a matter of misery loves company, it’s more along the lines of finding people who understand what you’re going through. And an online forum is the best place to do exactly that.
Medical Advice Forum
Tuesday, June 12th, 2007When it comes to medicine and health, the more advice we receive regarding our ailment or issue, the better. That’s why I was pleased to come across this sex advice forum and this general advice forum at Livingwithstyle.com. The LivingWithStyle.com forums advice forums mentioned above are peer operated and allow you to discuss whatever is troubling you with anonymity over the internet.
Let’s be honest, there are times that even talking to your doctor about what ails you can be hard. That’s why medical forums like these are continuing to gain in popularity. You can get basic advice from peers and then move on if you feel it is necessary. However, you should always be knowledgeable of the fact that these people are not trained professionals and that you should seek the advice of someone who is more knowledgeable if the issue is troubling or serious enough.
How about Dorian Yates Protein Supplements
Friday, June 8th, 2007Sports supplements are becoming more and more popular amongst anyone interested in improving their lifestyle, their health and well being and of course body image. Regular gym-goers are even turning to such sports supplements as the Dorian Yates Ultimate Formula’s, to improve their physiques and body strength. Looking good helps one to feel good, improving confidence, and self esteem. Feeling attractive and positive about one’s body has been shown to have hugely positive psychological benefits, with most successful people engaging in some form of strenous physical exercise as part of their lifestyle. The athletic world using Dorian Yates NoX Pump formula recognizes this highly respected athlete as a quiet, straight talking, no nonsense individual and a man of his word who is bringing to the market true performance enhancing sports supplements - ideal for those wishing to boost their performance and improve their physique development.
Chapter 2.0.Clinical Research Protocol .
Tuesday, June 5th, 2007
With this post begins the chapter 2. It´s about the clinical research protocol.
The protocol is a methodologist and administrative document where all the necessary information for the execution of an investigation is. In fact the protocol is the “handbook of operations” of all investigation.
TITLE OF THE INVESTIGATION
It must be short, precise and concise, leaving in clear the population to study, drugs to use (way of administration and dose), the primary target of the study and the principals variables to evaluate to arrive at that objective. If it is possible, in the title the design would have to be included. The title is the latest that must be written in a protocol and must be prepared to catch the attention of the reader.
Example: International, multicentric, stratified, randomized, double study blind person, with overload of placebo, in parallel groups (design) of gastrointestinal clinical security (variable to measure) of 48 weeks, to demonstrate more that (48 mg/day) (drug of the study) reduces the risk of developing complicated ulcers compared with 500 twice YYYYY mg per day (primary target and comparator) in patients with arthritis of hand of 65 years or (population).
Example: International, multicentric, stratified, randomized, double study blind person, with overload of placebo, in parallel groups (design) of gastrointestinal clinical security (variable to measure) of 48 weeks, to demonstrate more that (48 mg/day) (drug of the study) reduces the risk of developing complicated ulcers compared with 500 twice YYYYY mg per day (primary target and comparator) in patients with arthritis of hand of 65 years or (population).
BACKGROUND, RATIONALITY, JUSTIFICATION AND USE OF THE RESULTS
It describes the scientific antecedents related to the created problem and its resolution, obtained after an exhaustive bibliographical revision. It details the type of knowledge that is considered to obtain and the purpose that persecutes in terms of its application and its relation yet the well-known until the moment on the subject. Justification, that can be written as it leaves from I raise of the problem, must offer a convincing argument of which the generated knowledge is useful, applicable and has theoretical, methodological, social or practical value or. In this point the following questions are due to respond: How is related the investigation to the priorities of the disease in study and the effective treatments if it is that there are them? What knowledge and information are had on the subject? What information lacks and is desired to obtain on the base of the already existing thing? Which is the purpose that is persecuted with the knowledge that will offer the study? How will be scattered the results? How will be used the results and who will be the beneficiaries? SUMMARY It must give a clear idea, on which it is the central question that is tried to respond with the study of investigation and its justification. The hypotheses and the objectives of the investigation are due to mention. Also, the summary must contain a brief description of the population, the design, the methods and the procedures of the study.
EXPOSITION OF THE PROBLEM AND HYPOTHESIS
All investigation arises from a problem. The work hypothesis is the provisory answer that sets out to the problem that has considered and which is due to put under verification to see if it can be accepted like valid or be rejected. the hypothesis of a work is the key of the experimental design. A good hypothesis must have the following characteristics: 1) To be think in the planning of the study, not after the results are obtained. 2) To be logical, on the consistent fact that it wants to explain and with confirmed previous hypotheses. 3) To be simple and specific. 4) To be plausible of experimental contrast, that is that can on approval be put under, it can be expressed statistically and it must be able explain or predictive.
OBJECTIVES OF THE STUDY
They are the actions that will be carried out to prove the veracity of the raised hypothesis. The objectives must be necessary, enunciate what is expected of the study and be in context with the hypothesis. Many classifications of the objectives exist: specific, primary and secondary generals and, etc. In general one defines them after to have elaborated the theoretical foundation and to know clearly the sequence between the central question and the possible answers to the question and/or hypothesis of work. . General mission: he is the one that specifies what it is hoped to obtain with the study in knowledge terms. It gives a clear notion of which it is tried to describe, to determine, to identify, to compare and to verify. Example: “To verify that the drug To is as effective as drug B in the treatment of the Isolated 5istólica Hypertension in greater patients of 65 years and that has better tolerance”. Specific objectives: they are those that arise from the decomposition and the logical sequence of the general mission. They are an advance payment of the design of the investigation. Of his analysis it can: to identify population of study, to classify problem (that is to say, to determine if it is of quantification or relation of variables that is comparison/correlation) and to identify or the variables of the study (properties on which information is looking for) Examples of secondary targets for the mentioned primary objective above: . To determine the percentage of reduction of the arterial pressure after four weeks of treatment in both groups, that is the patients who take the medication To and those that take medication B 2. To consider the incidence of orthostatic hypotension in both groups, that is 105 patients who take the medication To and 105 that they take the B. To identify the incidence from adverse effects in both therapeutic groups
POPULATION OF STUDY I I
She is that on which they are wanted to apply the results of an investigation. Objective or white population is called because at her they point the conclusions of the investigation. The population of the study is characterized by the criteria of inclusion and exclusion of the investigation subjects. The inclusion criteria are characteristic specific that defines the white population. They can be more or less restrictive according to the objectives of the study. When stricter they are the criteria of inclusion of a clinical study the studied population will be more homogenous. This homogeneity, will facilitate the detection of differences between the drugs that study, in case they exist. Nevertheless, he will be more difficult extrapolar the results from the study to the general population that is much more heterogeneous. When the criteria of inclusion of a clinical study are ampler, the studied population will be more heterogeneous, therefore it is going to be more difficult to establish differences between the drugs that are studying. But, the conclusions of the clinical study will be able to be applied to a population of ampler reference. Let us see the differences between strict or ample criteria of inclusion in the following examples: the 1) anti-inflammatory clinical study To compares the effectiveness of two nonsteroids in patients who have pains you will articulate by rheumatoid arthritis. The population of the east study is patient with pain to articulate and rheumatoid arthritis (strict criterion). The patients with rheumatoid arthritis will react to studied drugs of similar way allowing one better evaluation of their effectiveness. But, the results of this investigation will be able to be applied only to patients who suffer pain to articulate by rheumatoid arthritis (similar to the population of the study) but will not be able to extrapolate themselves to patients with pains you will articulate caused by other pathologies ( osteoarthitis, etc). 2) anti-inflammatory clinical study 8 compares the effectiveness of two nonsteroids in patients who have pains you will articulate of different etiology (osteoarthitis, rheumatoid arthritis, trauma, etc). The population of the east study is patient with pain to articulate caused by different diseases or problems (wide criteria) that will react of way very different from studied drugs depending on the base disease. Nevertheless, the “results of this investigation will be able to be applied to all the patients with pain to articulate, population that approaches which we called general population. The exclusion criteria are characteristic specific that determines that the individuals cannot be including in a certain study of investigation. As the inclusion criteria the degree of laxitud of such affects to the homogeneity of the studied sample and the external validity of the study. The exclusion criteria allow: 1) To control variables that can confuse during the evaluation of the result of a certain study. 2) To give preeminence to the ethical aspects of the clinical investigation when leaving outside the clinical tests to individuals with the intention of protecting them. Some individuals that they want to participate in a clinical study like investigation subjects, can have a risk greater than the general population of the study by: to be carrying of certain diseases or to be treatment with certain drugs that harness the collateral effects of drugs in study, to present specific contraindications to some of the treatments of the study.
Summer Flowers. Aromatherapy recipes
Saturday, June 2nd, 2007http://digg.com/health/Aromatherapy_recipes
Summer is coming.What a diversity of flowers are surround us, they adorn the life symbolized the abiding love of the Great Spirit for all creatures. But do we think that flowers medicine is perfect , gently therapy, conducive to relaxation and healing?
I’d like to suggest you two aromatherapy health-giving recipes with using essential flowers oil.
1. Potpourri
Blend #1An exotic, citrus blend:
3 drop Jasmine
9 drops Sandalwood
12 drops Bergavot
6 drops Grapefruit
5 drops Oakmoss
2. Blend #4A warming spicy blend:
11 drops orange
6 drops ginger
8 drops cinnamon
1 drop nutmeg
4 drops frankincense
Have a sound mind in a sound body!